Arsenal set for £130m transfers, Man United snubbed, plus all the latest gossip

first_img Transfer Rumours and Paper Review 1 talkSPORT bring you a handy round-up all the top headlines and transfer-related stories in Saturday’s newspapers…Bayern Munich are prepared to pay £55m for Arsenal’s 28-year-old forward Alexis Sanchez, who is also a target for Chelsea, Juventus Manchester City and Paris Saint-Germain. (Sunday Telegraph)Arsenal are willing to pay £85m for Monaco striker Kylian Mbappe, 18, and offer him the incentive that he will play regular first-team football. (Mail on Sunday)And Mbappe is set to reject a big-money move to Manchester United because he does not like how Jose Mourinho’s team plays. (L’Equipe)Manchester City have made a £50m bid to sign Juventus left-back Alex Sandro, 26. (Sunday Mirror)Chelsea manager Antonio Conte has told the club’s owners to prioritise bringing back Everton striker Romelu Lukaku, 23, this summer. (Mail on Sunday)Manchester United boss Jose Mourinho aims to make a £55m bid to sign Manchester City striker Sergio Aguero, 28. (Sun on Sunday)Chelsea are ready to make a £20m move for 22-year-old Italian midfielder Domenico Berardi from Sassuolo. (Sunday Mirror)Stoke City are set to try to sign Chelsea captain John Terry, 36, in the summer, although they face competition from teams in America’s Major League Soccer as well as the Chinese Super League. (Sun on Sunday)Manchester United goalkeeper David de Gea, 26, is set to move to Real Madrid with United looking to replace him with Atletico Madrid’s Jan Oblak, 24. (Don Balon)Manchester City are monitoring Schalke left-back Sead Kolasinac. The 23-year-old will be available on a free transfer, but City are yet to make an offer. (Manchester Evening News)Liverpool should try to sign three more Southampton players, according to former Reds captain Phil Thompson. The Reds are interested in centre-half Virgil van Dijk, 25, left-back Ryan Bertrand, 27, and central midfielder Oriol Romeu, 25. (Liverpool Echo)Here are the latest talkSPORT.com headlines: Former Tottenham boss Tim Sherwood has praised the work of manager Mauricio Pochettino – but believes the current side need to win silverware to push on againTorino president Urbano Cairo has revealed Manchester City have given no indication over their intentions with goalkeeper Joe HartBorussia Dortmund have joined Chelsea and Juventus in the race for Celtic striker Moussa DembeleSchalke star Sead Kolasinac is expected to decide between offers from AC Milan, Arsenal and Manchester City next weeklast_img read more

Giants break with tradition, change home game start times

first_imgSAN FRANCISCO–Don’t plan on showing up at 7:15 p.m. for weeknight games at AT&T Park next season.In a letter to season-ticket holders Tuesday, Giants CEO Larry Baer announced that the club plans to break with tradition and move the start times of weeknight home games up 30 minutes to 6:45 p.m. The change does not include games scheduled for Fridays.Baer said the Giants have made the switch to “better serve families and fans during the work week,” and promised more details in the coming weeks. …last_img

Warriors-Thunder cheatsheet: Here comes a red-hot OKC team

first_imgAfter losing all three games during their Texas Three Step road trip (read about those here, here and here), can the Warriors (12-6) get back on track against the red-hot Thunder (10-6)?When/Where: Oracle Arena, 7:30 p.m.Projected Thunder starters: Russell Westbrook, Paul George, Steven Adams, Jerami Grant, Hamidou DialloHow the Thunder are doing: After losing their first four games of the season, the Thunder come into Wednesday’s game one of the hottest teams in the Western Conference, …last_img

Cell Gatekeepers: Diverse, Complex, Accurate

first_imgCargo moves around rapidly and ceaselessly in every cell.  Some moves in and out of the external membrane, and some moves in and out of organelles and the nucleus.  In a system of protected domains surrounded by impermeable membranes, how does the cell control what should pass?  Details of the amazing gatekeeping mechanisms embedded in cell membranes have been coming to light for years now.  Some recent articles have reported the latest findings. Protective sleeve:  One method of getting valid cargo through the membrane gate is to wrap it in a protective sleeve that the gate recognizes.  PhysOrg has an illustration from the work of a team at Purdue showing how this works.  What comes to mind is a personal subway capsule that shuttles you to an escalator that transfers you safely into a shopping mall without any intruders getting past.Electronic gating:  Ions are electrically-charged atoms whose concentration in the cell must be strictly controlled.  Compared to the large molecules of the cell, ions of potassium, chlorine and sodium are tiny.  Special voltage-sensing gates exist just for them.  We reported here on early results from work by Roderick MacKinnon into the structure and function of these ionic gates (see 01/17/2002, 05/29/2002, 05/01/2003, 08/05/2005).    The November issue of The Scientist describes ongoing discoveries about one of these voltage-gated channels, the Kv potassium channel.  This electronic mechanism contains a pore, a gate and a voltage sensor.  In particular, a key helix protein component called S4 undergoes a conformational change to open the gate for the potassium ion.  People who enjoy exercise may want to reflect that all nerve and muscle activity depends on the proper control of these ions.Nuclear power plant security:  For those wanting to follow up on news about the nucleus, and how it controls the cargo going in and out (see last month’s entry, 11/13/2007, bullet #2), the crew of your nuclear power plant made the cover of Science this week.  Laura Trinkle-Mulcahy and Angus I. Lamond reviewed the latest work to get high-resolution images of the complex structures and functions of the nuclear membrane, especially the gates of the nuclear pore complex (NPC).1    Four other articles in the 11/30 issue describe the latest findings about the cell nucleus.  A paper by 3 Vanderbilt University scientists specifically addresses the factors involved in crossing the nuclear envelope through the NPC gates.2  For those wanting more information about the sensing mechanism, their article contained color diagrams of the structures.  The scientists explained how the gates are regulated at multiple levels – a philosophy common in national security and computer security, too.  The “dynamic and diverse” mechanisms control what passes at the gate level, the transport receptor level, and the cargo level.  In computer parlance, this might be analogous to requiring a fingerprint, a secure computer, and secure software before you are allowed to login.    Another paper in the same issue of Science describes science’s growing realization that the nuclear membrane does far more than let things in and out.3  It is actively involved in cell division, structuring the cytoskeleton, and signaling other processes in the cell.  The nuclear envelope is also connected to the endoplasmic reticulum, a structure essential for post-translational modification of proteins.  The authors did not mention how these elaborate mechanisms might have evolved, except to say twice that they raise “intriguing questions” and “fundamental questions” about “evolutionary relations” between the parts.  The other two papers did not mention evolution at all.ER: emergency room or endoplasmic reticulum:  Speaking of the endoplasmic reticulum (a kind of subway system within the cell), Nature reported studies about the transport channels in that organelle.4  “A decisive step in the biosynthesis of many proteins is their partial or complete translocation across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane,” began Tom Rapoport (Howard Hughes Medical Institute, Harvard).  “Most of these proteins are translocated through a protein-conducting channel that is formed by a conserved, heterotrimeric membrane-protein complex, the Sec61 or SecY complex.”    Polypeptides are the pre-protein strings of amino acids emerging from ribosomes, where the translation from RNA occurs.  Getting a wobbly chain of molecules through a pore is somewhat akin to threading a needle.  Depending on what the cargo binds to, it may get in by one of several ways: the ribosome may simply attach to and inject the nascent polypeptide into the channel, an ER chaperone might pump it in by a ratcheting mechanism, or a molecular machine running on ATP might push the polypeptide through.  These are all regulated by a host of assisting proteins that keep in touch through signaling mechanisms.  There’s even a plug that closes the channel after the polypeptide is inside.    Rapoport provided a diagram of the complicated-looking translocation channel, which is made up of three different protein parts.  He called it conserved (unevolved) between all three kingdoms of life, but did not say anything else about evolution – certainly, not anything about how it arose in the first place.Light sensitive:  Imagine a receptor on a cell membrane that can respond to one photon of light, and send a signal into the interior.  You don’t have to imagine it: it already exists.  Rama Ranganathan in Science described the family of G-protein coupled receptors (GPCR) that “occur in nearly every eukaryotic cell and can sense photons, cations, small molecules, peptides, and proteins.”5  How do they do it?  The structures of these receptors are just beginning to come to light, and basic models are being formulated.  Stay tuned.Most of the articles above said nothing about how these complex transportation systems might have evolved.  A review in Nature,6 however, proposed that “the plethora of transport factors found in modern eukaryotes may have also evolved by duplication events, keeping pace with the evolutionary duplication and diverging specialization of the FG nucleoporins in the NPC’s [nuclear pore complex’s] modules.”  Noting some similarities in the NPC to clathrin-coated endocytosis, the team of a dozen UK and American scientists suggested that gene duplication was the method of evolution: “the NPC is another example of how a complicated structure can evolve from the duplication, divergence and elaboration of simple ancestral modules,” they claimed.  They also downplayed the complexity of the NPC by pointing out some of the proteins are used in a modular fashion.  A summary and diagram was posted by PhysOrg.    Their evolutionary explanation, however, was based entirely on circumstantial evidence of similarity, not on a chain of plausible steps for how diverse mechanisms, despite some structural similarities, achieved their high levels of functional accuracy.1.  Laura Trinkle-Mulcahy and Angus I. Lamond, “Toward a High-Resolution View of Nuclear Dynamics,” Science, 30 November 2007: Vol. 318. no. 5855, pp. 1402-1407, DOI: 10.1126/science.1142033.2.  Laura J. Terry, Eric B. Shows, Susan R. Wente, “Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport,” Science, 30 November 2007: Vol. 318. no. 5855, pp. 1412-1416, DOI: 10.1126/science.1142204.3.  Colin L. Stewart, Kyle J. Roux, Brian Burke, “Blurring the Boundary: The Nuclear Envelope Extends Its Reach,” Science, 30 November 2007: Vol. 318. no. 5855, pp. 1408-1412, DOI: 10.1126/science.1142034.4.  Tom O. Rapoport, “Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes,” Nature 450, 663-669 (29 November 2007) | doi:10.1038/nature06384.5.  Rama Ranganathan, “Signaling Across the Cell Membrane,” Science, 23 November 2007: Vol. 318. no. 5854, pp. 1253-1254, DOI: 10.1126/science.1151656.6.  Alber et al, “The molecular architecture of the nuclear pore complex,” Nature 450, 695-701 (29 November 2007) | doi:10.1038/nature06405.The evolutionary speculations in Nature provided nothing to the real scientific work in these papers.  They did not help determine the structure, function or dynamics of any of the transport mechanisms.  They were mere after-the-fact pipe dreams about how Charlie might be vindicated with a hefty dose of LSD (Let’s Support Darwin).    Gene duplication is pitifully incapable of explaining how functional information got into either clathrin-coated endocytosis or nuclear pore transport.  A motorcycle and a diesel train have some similarities, too; they both have wheels that rotate and are powered by fuels that have some similarities (hydrocarbons).  So what?  You can duplicate as many motorcycles as you want, for eternity, and will never get a bullet train.  Even if you allow the duplicate motorcycle unlimited free mutations, will that help?  Try breaking things at random on the motorcycle and see if you make progress toward train technology.  Darwinian evolution is blind, remember.  It has no foresight.  It is not trying to work toward traindom.  Unless each mistake provides some advantage for the here and now, the only likely result is that repeated mutations will leave you stranded on the highway bumming a ride.    Sorry we had to waste time on evolution.  The focus of this story should be on the amazing mechanisms of the cell, and how modern science is slowly pulling back the cover on the package so we can all, with the fascination of kids at Christmas, look inside and see the words LION-EL.*(Visited 9 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

TV series: ordinary people show the way

first_img1 November 2011The third episode of Brand South Africa’s Play Your Part TV series, featuring up-and-coming musician Brandon Phillips, community farmer Jimmy Botha, and high school with a difference The Ethembeni Enrichment Centre, broadcasts on SABC 1 at 12h30 on Sunday, 6 November.The 13-part television series promoting Brand SA’s Play Your Part campaign features inspirational stories of ordinary citizens getting out there to change the lives of others in their neighbourhoods, their communities and their cities.Brand SA has travelled the length and breadth of the country asking ordinary South Africans how they are playing their part for positive social change, in the process uncovering a range of inspirational stories to share with the nation.From humble roots, pursuing excellenceThis week, the show features Brandon Phillips, who has broken into an artistic field that was the preserve of white South Africans.As principal bassoonist for the Cape Philharmonic Orchestra, and winner of the inaugural Len van Zyl Conductors Competition, Phillips is the heir-apparent for the illustrious position as the orchestra’s conductor – quite a journey for the young man whose first gig was in a small ensemble in his local church in Mitchell’s Plain.The serene mountains of the Magaliesburg are a far cry from the loud sounds and hard streets of Westbury, where Jimmy Botha spent much of his youth. Farming was the unlikeliest of career paths for a city boy who had spent his adult life as a contractor for one the country’s largest telecoms corporations.But tilling the land has brought unexpected joy to Botha, who now runs the successful Tila’s Herbs farm, which has brought much needed employment opportunities for the local population.Applying the right basic principlesThe Ethembeni Enrichment Centre began its life as a response the education crisis that had crippled the country’s township schools. The idea was to provide a place for matric students who wanted to improve their marks. Today the school has over 400 students, and is a fully fledged high school teaching grades 8-12.Ethembeni’s secret seems to lie in the five basics that are strictly adhered to: 100% attendance; completion of homework; parent involvement; respect for property and people; and punctuality.Through these, Ethembeni has turned the tide on the low morale and ill-discipline that plagues so many schools in similar circumstances – in the process becoming the largest student feeder for the University of Port Elizabeth.‘Each one of us can make a difference’“There are a number of opportunities, big and small, where each and every one of us can make a positive difference in the communities in which we live and operate,” Brand South Africa CEO Miller Matola said at the launch of the new show.The TV series “will lift the spirits and inspire all South Africans with examples of how their fellow citizens are creating a South Africa we can all be proud of”.Play Your Part is a social movement created by the Brand South Africa to inspire, empower and celebrate active citizenship. For more information, visit www.playyourpart.co.za.SAinfo reporterlast_img read more

Data Access up in the Air

first_imgTwo announcements over the last couple of days stand in an interesting contrast to each other.  One is Google’s announcement of Google WiFi and the availability of free WiFi access across all of the city of Mountain View.  The second is Boeing’s announcement to exit from providing WiFi access on board carriers flying Boeing aircraft in December 2006, after having equipped 156 aircraft with their Connexion service, including those from carriers like Lufthansa, SAS and Singapore Airlines. (This follows an announcement in June of Verizon to also exit the in-flight phone business.)Access to things like VoIP, web-based on-line services and data content, like that of our own Formtek | Orion repository, or any of hundreds of other kinds of services from anywhere and anyplace is enticing.  The net is becoming (or has become) the driving force for business communication and data.  Google’s roll-out across the entire city of Mountain View seems to have been challenging and have had a few glitches.  All transmitters are not in place just yet either.  Also the disclaimer that the service is an “outdoor service” and does not work well in-doors is a bit disappointing.  Considering the service has only been up a few days, it seems to be doing well — I’m looking forward to the planned roll-out in San Francisco.The exit of Boeing and Verizon from in-flight WiFi might prove to be an interesting alternative for Google.  For example, immediately after Boeing’s announcement ASiQ in turn announced that they see Boeing’s exit as greater opportunity for them.  Boeing’s Connexion was based on technology circa 2000.  It’s only six years, but technology has changed quickly and ASiQ has developed a much cheaper alternative. There has been a lot of press about Google’s efforts to try to penetrate the Enterprise market.  While free community-wide net access is great (especially if it is somewhere that I’ll be frequently), I wonder that if Google is really serious about the Enterprise that it might be a better and more cost-effective strategy for them to provide free WiFi in places like airports and airplanes, places where business people are in high numbers.  It seems like it would be far easier and have fewer obstacles in getting approval to do something like that rather than to try to blanket the landscape of an entire community with WiFi.last_img read more

Creating Beautiful Slow Motion in Adobe Premiere Pro

first_imgSlow-motion video can be beautiful, if executed correctly. Here, we take a look at creating slow-motion from 60fps video in Premiere Pro.Don’t make the mistake of slowing down standard frame rate video for slow motion. It’ll give your footage a choppy look, and it doesn’t present well.Instead, to make smooth slow-mo, you’ll need to shoot your footage at a high frame rate, and then play back your footage at a lower frame rate in your video editing app. Most DSLRs and mirrorless cameras can shoot 720p or even 1080p at 60 frames-per-second (fps). If you don’t have a camera that can shoot up to 60fps, check out our list of the most affordable options. Shooting at 60fps allows you to play back your footage at a slower fps (like 24fps), while still maintaining a streamlined, cinematic look.In this walkthrough, we’ll show you how to create a similar effect by converting 60fps footage to 24fps in Premiere Pro. These are just the foundation slow motion features in Premiere, so once you get comfortable with the frame rate interpretation and time remapping settings, take a look at the video below that goes into using keyframes in your timeline to speed ramp your footage. 1. Slow Down in Your TimelineThis one is simple and straightforward. Create a 24fps sequence.Place a 60fps clip in your 24p timeline. Right-click the clip, and make sure frame blending is OFF.Right-click the clip and go to “Speed/Duration” (⌘R).Set your speed to 40% (40% is going to be the lowest you can go without making your footage choppy). If you’re working in a frame rate other than 24 fps, you’ll have to determine your speed by dividing your destination frame rate by your clip’s frame rate (e.g. 24/60=.4).Now, your footage is in smooth slow-motion. You’ll notice that every frame plays back and there is no frame blending. Beautiful!2. Re-Interpret Frame RateThis is the way I usually conform 60fps clips into slo-mo. (This is also a good way to make multiple clips slo-mo in one simple step.) This will make the selected clips in your bin slow-motion, so if you want to keep your original 100% speed clips in your project, you’ll want to duplicate them before doing this.Select the clips in your bin that you want to make slo-mo.Right-click and select “Modify > Interpret Footage.”Select “Assume this frame rate” and set the value to your timeline’s frame rate.Done. Now, Premiere will reorganize and stretch the existing frames in your 60fps clip to conform to a 24fps sequence.By implementing these simple techniques, using 60fps video to create slow-motion in Premiere Pro is easy.Looking for more video production tips and tricks? Check out these articles.Editing Tips: Sorting Footage and Creating Quality TimelinesWhy You Should Wait to Download Your NLE’s Beta ReleaseQuick and Easy Tips on Shooting and Processing Day for Night Getting Creative: Five Cool Video Edits that Genuinely WorkProduction Tip: How to Calculate Power for Your Cameralast_img read more

10 months ago​Robertson deflects praise to Liverpool teammate Clyne

first_img​Robertson deflects praise to Liverpool teammate Clyneby Freddie Taylor10 months agoSend to a friendShare the loveLiverpool full back Andy Robertson is not one to have an inflated ego.And despite praise from then Manchester United manager Jose Mourinho after Liverpool’s 3-1 win over the Red Devils, Roberston was in a graceful mood.He preferred to talk up his teammates for their impressive performances in the league win.He said of Mourinho’s comments after the game that he ran all day: “It is just part and parcel of my game, I will keep on going until the end.”I got a bit of space, particularly second half and the gaffer is always banging on to me and Trent, more so this season, that we have to be more involved and I was just tried to do that.”Special mention goes to Clyney today, being out for so long and my God, he done brilliant. He has had his struggles with injury but he put in a first-class performance and that just sums up our squad at the minute.” About the authorFreddie TaylorShare the loveHave your saylast_img read more

10 months agoLuiz reveals Cesc gave farewell speech to Chelsea players

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Luiz reveals Cesc gave farewell speech to Chelsea playersby Paul Vegas10 months agoSend to a friendShare the loveDavid Luiz has revealed Cesc Fabregas gave a formal farewell speech to Chelsea’s players over the weekend.While no deal with Monaco is as yet confirmed, Fabregas is expected to soon sign for them.“He did a speech and then after that we all say thank you for him, and hug him,” David Luiz revealed.“I think it’s an emotional day not just for him, for everybody. One of the best players playing in England was him, everyone knows that. Sad for everybody when you lose this kind of player, this kind of person, but I think everybody has to stand up and clap the hands for him because he deserves it.“It’s always difficult to lose players, especially like him, because like I say he’s a world-class player but also I understand it’s part of the process, and if it’s better for him and better for the club, we have to understand that.”Fabregas won two Premier League titles, a League Cup and an FA Cup with Chelsea, and Luiz said it was that champion’s assertiveness that would remain in the memory.“I think he won everything with this club. My memories are always going to be with the world-class player, with the great technique, he’s a great guy.“He has experience. He knows football, I think he had the opportunity to learn in many different changing rooms when he was so young, before, so he brings always a confidence, energy for the team, and then in the pitch he showed that it doesn’t matter the game, he’s always going to show his qualities. Sad. It’s really sad for us. We are wishing him all the best, because he deserves it.” last_img read more

9 months agoSouthampton, Man City target Leeds youngster Jack Clarke

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say Southampton, Man City target Leeds youngster Jack Clarkeby Paul Vegas9 months agoSend to a friendShare the loveLeeds United have warned suitors off teenage starlet Jack Clarke.Southampton boss Ralph Hasenhuttl has joined Manchester City rival Pep Guardiola in showing interest in the 18-year-old Clarke because of his storming debut campaign for Leeds.But Leeds are adamant academy-product Clarke is not for sale and want the winger to grow with them, hopefully next season in the Premier League, reports the Mirror.Leeds have shown their faith in Clarke by handing him the biggest contact for an Under-18 player in their history and his deal has three years left to run. last_img