Information leaked to Cherwell last week suggests that Oxford Fashion Week is struggling to sell tickets for its most expensive shows. Some ticket reps are also complaining that the perks offered to them are not enough for the work they put in.The annual fashion week kicks off this Sunday but according to an e-mail sent to ticket reps two weeks ago, the company had sold just seventeen tickets for the £35 “Concept Show” and only six tickets for their £55 Malmaison Lingerie Show. The considerably cheaper £6 Style Show had reportedly sold over 125 tickets.This year’s Fashion Week has recently announced the addition of two Lady Gaga costumes, which will feature in the Couture Show as well as the return of Fashion journalist Dolly Jones, editor of VOGUE.COM, who will be joining the Oxford Fashion Week forum on Monday. However, students are complaining that the week’s events are unrealistically expensive even with these new inclusions.OFW found it difficult to sell tickets for their pricier events last year in the run up to the week. The business made an overall financial loss for that year’s event.Although the company declined to comment on current sales figures, Carl Anglim, CEO of OFW, defended the company’s decision to keep prices high. He promised that this year’s Fashion Show will “be far and away the most luxurious evening of the week at Oxford’s dramatic converted prison”.For its second year, OFW decided to recruit College Representatives to raise awareness of the week and further increase ticket sales. Mr Anglim said, “The primary role of College Reps is to provide a point of information in each college and to bring OFW closer to students. We are delighted to have so many who have volunteered to help”.However, some ticket reps blame the lack of perks offered by the company for poor ticket sales.One representative for the week told Cherwell that she had not sold any tickets. “I can’t really be bothered. It’s all very overpriced and there aren’t many incentives. If you sell over £100 worth of tickets you get a free ticket to the Style show, which is hardly worth pushing sales for considering that it is by far the cheapest event”.Another student, who wished to remain anonymous, dropped out of selling tickets. She said, “There’s some free stuff for ticket reps but only if you sell enough tickets. It’s a tad exploitative. Plus I think everything is way too expensive so I didn’t feel comfortable selling people tickets”.The criticisms follow other difficulties in what has been a difficult second year for Oxford’s biggest fashion event. Earlier in the year, the company had to scale down the Week from six events to five. The sixth event, a Couture show, was allegedly cancelled following “a big row about budgets and the way OFW was presenting itself,” according to one insider.However, Mr Anglim has rejected these claims, saying for the Couture Show “the elements were not in place at the right time for the scale of event we wanted.”
Bamberger, SKO Merger CompleteIL for www.theindianalawyer.comThe merger between Evansville-based Bamberger Foreman Oswald & Hahn LLP and Kentucky-based Stoll Keenon Ogden PLLC was completed Tuesday, one month ahead of the expected closure date.Bamberger, founded in 1959, and SKO announced the combining of their firms at the end of June. As part of the merger, Bamberger’s offices in Evansville and Indianapolis are now operating as Stoll Keenon Ogden and the Evansville attorneys will be relocating from the Hulman Building to join the SKO office in the Old National Bank headquarters.“Attorneys and staff on both sides have worked diligently to ensure we were able to conclude this in a short time, and they are to be commended,” said SKO managing director P. Douglas Barr. “The entire firm is now fully engaged in looking toward the future with expanded legal services, deep bench strength in key practice areas, and a significantly enhanced presence across Indiana to offer our clients.”Stoll Keenon Ogden traces its roots to 1897 and currently has 144 attorneys working in Louisville, Lexington and Frankfort, Kentucky, and Pittsburgh, Pennsylvania, as well as Evansville and Indianapolis. The merger with Bamberger more than doubles SKO’s number of attorneys licensed to practice law in the Hoosier state.FacebookTwitterCopy LinkEmail
Say hello to Southern California’s newest music festival, Same Same But Different (SSBD), coming September 22nd and 23rd, 2018. This inaugural two-day music & arts festival will celebrate the end of summer in a jaw-dropping setting and feature a diverse range of multi-genre musical acts that build in energy throughout the day.On Saturday, performances from Lettuce, Boombox, Through The Roots, The Family Crest, and more will take place across the festival’s two stages. Then on Sunday, headliners The Floozies, will be joined by KNOWER, Moon Hooch, Dirtwire, Capyac, and more. Performances will alternate across the two stages allowing attendees to experience each artist on the lineup without having to choose between overlapping set-times.Same Same But Different is as much about the music and arts as it is about the location. SSBD will take place at the picturesque Lake Perris Recreational Campgrounds, located just outside of Los Angeles and San Diego. Recognized as one of Southern California’s most beautiful campgrounds, Lake Perris Campground sits above it’s namesake lake and offers a variety of water recreation including swimming, fishing (shore, pier, and boat), boating, sailing, waterskiing, and scuba diving. Attendees will also be able to explore the location’s natural wonders along dedicated hiking, biking, and equestrian trails within the park, as well as enjoy festival yoga and meditation courses. This perfect weekend getaway will even feature an art-zone where guests can participate in one-of-a-kind art classes and live art installations.Festival organizers Peter Eichar and Brad Sweet explain, “we wanted to create an intimate music festival that we would personally want to attend; something to fill the gap between huge mega-festivals Southern California is home to, and smaller niche festivals that are usually genre specific.” Eichar continues, “We know what it’s like to spend an entire paycheck on a festival weekend only to get there and be stuck in the back of a massive crowd. We want to provide an alternative to that experience without sacrificing the quality of music and the overall vibe.”To purchase tickets to Same Same But Different, please visit the event website.
Facebook1Tweet0Pin0Hi I’m LUCY! I have an extremely enthusiastic attitude towards life, and thrive on exercise. If you have a big yard, and a lot of energy, we’ll be a perfect fit! I’m a beautiful Chocolate Lab mix, with a very cheerful nature. I know my basic commands, and really enjoy going for rides in the car, especially if we can go explore and maybe go for a swim? I prefer to be around older kids (13+) and I think I can get along well with other dogs, if we are properly introduced… No blind dates please J! (Also, no cats for me) I’m a kind, intelligent family oriented girl just waiting to meet you. I currently weigh around 60#, and would adore a cuddle on the couch. Please come see me soon…I can’t wait to meet you!Adopt-A-Pet has many great dogs and always need volunteers. To see all our current dogs, visit www.adoptapet-wa.org, Facebook at “Adopt-A-Pet of Shelton Washington” or at the shelter on Jensen Road in Shelton. For more information, visit [email protected] or 360-432-3091.
About Commencement BankCommencement Bank, headquartered in Tacoma, Washington, was formed in 2006 to provide traditional, reliable, and sustainable banking in Pierce County, South King County and the surrounding areas. The team of experienced banking experts focuses on personal attention, flexible service, and building strong relationships with customers through state of the art technology as well as traditional delivery systems. As a local bank, Commencement Bank is deeply committed to the community. For more information, please visit www.commencementbank.com. Facebook2Tweet0Pin0Submitted by Thurston First BankJim Haley, President and Chief Executive Officer of Olympia-based Thurston First Bank (a Division of Commencement Bank), has formally announced his retirement. Prior to his role as president and CEO, Haley served as chief credit officer for Thurston First Bank from 2004 to 2008. Over the past nine years, he successfully led the Bank through the recession and the recent merger with Commencement Bank.In 2014, after relocating Thurston First Bank’s headquarters to 600 Franklin Street, Haley played a pivotal role in the revitalization of Downtown Olympia. Haley served on the boards of various community and civic organizations, including past chairman for the Community Bankers of Washington and current president for The Washington Center for the Performing Arts. In addition to remaining involved in the community, Haley plans to devote more time to his family, especially his two grandchildren.Thurston First Bank has merged with Tacoma-based Commencement Bank. The bank will retain it’s local moniker for at least the first 12 months.“My journey with the Thurston First Bank staff and board of directors has been truly rewarding, and the experiences I’ve gained from my time spent in Olympia are invaluable. It’s been an honor to work in such a diverse and supportive community, and I’m excited to see the benefit that the new combined bank will have on Thurston County and downtown.”Haley’s passion for Olympia and his dedication to the local businesses will continue to be expressed through the Thurston First and Commencement Bank team. Commencement Bank President & CEO Hal Russell will assume Haley’s administrative and leadership responsibilities and is committed to being an active supporter of the Downtown Olympia community. About Thurston First BankThurston First Bank, headquartered in Olympia, Washington, was founded in 2004 and designed to provide businesses and professionals with knowledge and resources of innovative banking solutions that did not previously exist in Thurston County. It has earned an excellent reputation for integrity, personalized service, technology-based solutions, and a highly valued base of exceptional clients and partners. As a local bank, it is committed to promoting social and cultural growth by reinvesting in the community. To learn more about Thurston First Bank, please visit www.thurstonfirstbank.com.
The Kootenay Ice pushed the Greater Vancouver Canadians to the limit before dropping a pair of tough BC Hockey Major Midget League games this past weekend in Richmond.Kootenay opened losing 4-1 Saturday before suffering a heartbreaking 1-0 setback Sunday to the Lower Mainland power.Saturday, Kootenay trailed 2-1 entering the third period before the hosts scored twice in the frame to escape with the win.The games were the first of the season for the Ice, which opened the season with a bye weekend.Shawn Campbell scored the lone goal for the Ice. Tyson Lin scored twice to lead the Canadians.Sunday, a goal by Brennan Gaytmenn early in the first period stood up as the winner sparking Greater Vancouver to the slim one-goal victory.Curt Doyle and Ben Kelsch, both of Nelson, shared the netminder duties for Kootenay.Kootenay ices a lineup consisting of players from throughout the Kootenay region, including players from Castlegar, Trail, Nakusp, Kimberley as well as Vernon, Vancouver and Vanderhoof.Kootenay returns to action this weekend in Kamloops when the Ice face the Thompson Blazers.First home action for Kootenay is Saturday, October 17 when the Ice host the Valley West Hawks at 7 p.m. in the NDCC Arena. The teams close out the weekend series Sunday, October 18 at 10 a.m. in Nelson.The BC Hockey Major Midget League was established in 2004 to provide elite level 15, 16 and 17 year olds an opportunity to play within their own age group at a high level and be developed for the next level of hockey.The winning team has the opportunity each year to compete for the National Midget Championship.
The Bob Ursel rink of Kelowna, with half the rink from the West Kootenay, began defence of its 2016 BC Senior Men’s Curling title by sweeping past the competition during regional playdowns Sunday in Kelowna.Ursel, third Dave Stephenson, Trail second Don Freschi and Nelson lead Fred Thomson, defeated Mark Longworth of Vernon 4-1 Sunday in the B Final to clinch the Okanagan berth.Ursel dumped Longworth 7-4 Saturday in the A Final after opening the four-team playdown with an 11-4 win over Frank Cseke of Salmon Arm.
Xtreme Youth Football and Cheer has scheduled registration dates for its 2007 season. The team focuses its recruiting in Montebello, Monterey Park and the City of Commerce, however, the Xtreme will accept anyone from any city. Sign-ups are slated from 10 a.m.-2 p.m., every Saturday in March, at Barnes Park, 350 S. McPherrin Ave., Monterey Park. For information call (877) 987-3633 or visit www.eteamz.com/goxtreme. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
Indefensible. Revolutionary. Transcendent. These are words some NFL analysts have used to describe what makes Lamar Jackson and the Baltimore Ravens offense so dominant.But maybe the simplest explanation for what makes them so special can be summed up this way: You can’t stop what you can’t see.“Even on television, I had no idea where the football is,” said Dan Orlovsky, an ESPN analyst and ex-NFL quarterback who watched the Ravens annihilate the Rams 45-6 on Monday Night Football. “Imagine …
Cargo moves around rapidly and ceaselessly in every cell. Some moves in and out of the external membrane, and some moves in and out of organelles and the nucleus. In a system of protected domains surrounded by impermeable membranes, how does the cell control what should pass? Details of the amazing gatekeeping mechanisms embedded in cell membranes have been coming to light for years now. Some recent articles have reported the latest findings. Protective sleeve: One method of getting valid cargo through the membrane gate is to wrap it in a protective sleeve that the gate recognizes. PhysOrg has an illustration from the work of a team at Purdue showing how this works. What comes to mind is a personal subway capsule that shuttles you to an escalator that transfers you safely into a shopping mall without any intruders getting past.Electronic gating: Ions are electrically-charged atoms whose concentration in the cell must be strictly controlled. Compared to the large molecules of the cell, ions of potassium, chlorine and sodium are tiny. Special voltage-sensing gates exist just for them. We reported here on early results from work by Roderick MacKinnon into the structure and function of these ionic gates (see 01/17/2002, 05/29/2002, 05/01/2003, 08/05/2005). The November issue of The Scientist describes ongoing discoveries about one of these voltage-gated channels, the Kv potassium channel. This electronic mechanism contains a pore, a gate and a voltage sensor. In particular, a key helix protein component called S4 undergoes a conformational change to open the gate for the potassium ion. People who enjoy exercise may want to reflect that all nerve and muscle activity depends on the proper control of these ions.Nuclear power plant security: For those wanting to follow up on news about the nucleus, and how it controls the cargo going in and out (see last month’s entry, 11/13/2007, bullet #2), the crew of your nuclear power plant made the cover of Science this week. Laura Trinkle-Mulcahy and Angus I. Lamond reviewed the latest work to get high-resolution images of the complex structures and functions of the nuclear membrane, especially the gates of the nuclear pore complex (NPC).1 Four other articles in the 11/30 issue describe the latest findings about the cell nucleus. A paper by 3 Vanderbilt University scientists specifically addresses the factors involved in crossing the nuclear envelope through the NPC gates.2 For those wanting more information about the sensing mechanism, their article contained color diagrams of the structures. The scientists explained how the gates are regulated at multiple levels – a philosophy common in national security and computer security, too. The “dynamic and diverse” mechanisms control what passes at the gate level, the transport receptor level, and the cargo level. In computer parlance, this might be analogous to requiring a fingerprint, a secure computer, and secure software before you are allowed to login. Another paper in the same issue of Science describes science’s growing realization that the nuclear membrane does far more than let things in and out.3 It is actively involved in cell division, structuring the cytoskeleton, and signaling other processes in the cell. The nuclear envelope is also connected to the endoplasmic reticulum, a structure essential for post-translational modification of proteins. The authors did not mention how these elaborate mechanisms might have evolved, except to say twice that they raise “intriguing questions” and “fundamental questions” about “evolutionary relations” between the parts. The other two papers did not mention evolution at all.ER: emergency room or endoplasmic reticulum: Speaking of the endoplasmic reticulum (a kind of subway system within the cell), Nature reported studies about the transport channels in that organelle.4 “A decisive step in the biosynthesis of many proteins is their partial or complete translocation across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane,” began Tom Rapoport (Howard Hughes Medical Institute, Harvard). “Most of these proteins are translocated through a protein-conducting channel that is formed by a conserved, heterotrimeric membrane-protein complex, the Sec61 or SecY complex.” Polypeptides are the pre-protein strings of amino acids emerging from ribosomes, where the translation from RNA occurs. Getting a wobbly chain of molecules through a pore is somewhat akin to threading a needle. Depending on what the cargo binds to, it may get in by one of several ways: the ribosome may simply attach to and inject the nascent polypeptide into the channel, an ER chaperone might pump it in by a ratcheting mechanism, or a molecular machine running on ATP might push the polypeptide through. These are all regulated by a host of assisting proteins that keep in touch through signaling mechanisms. There’s even a plug that closes the channel after the polypeptide is inside. Rapoport provided a diagram of the complicated-looking translocation channel, which is made up of three different protein parts. He called it conserved (unevolved) between all three kingdoms of life, but did not say anything else about evolution – certainly, not anything about how it arose in the first place.Light sensitive: Imagine a receptor on a cell membrane that can respond to one photon of light, and send a signal into the interior. You don’t have to imagine it: it already exists. Rama Ranganathan in Science described the family of G-protein coupled receptors (GPCR) that “occur in nearly every eukaryotic cell and can sense photons, cations, small molecules, peptides, and proteins.”5 How do they do it? The structures of these receptors are just beginning to come to light, and basic models are being formulated. Stay tuned.Most of the articles above said nothing about how these complex transportation systems might have evolved. A review in Nature,6 however, proposed that “the plethora of transport factors found in modern eukaryotes may have also evolved by duplication events, keeping pace with the evolutionary duplication and diverging specialization of the FG nucleoporins in the NPC’s [nuclear pore complex’s] modules.” Noting some similarities in the NPC to clathrin-coated endocytosis, the team of a dozen UK and American scientists suggested that gene duplication was the method of evolution: “the NPC is another example of how a complicated structure can evolve from the duplication, divergence and elaboration of simple ancestral modules,” they claimed. They also downplayed the complexity of the NPC by pointing out some of the proteins are used in a modular fashion. A summary and diagram was posted by PhysOrg. Their evolutionary explanation, however, was based entirely on circumstantial evidence of similarity, not on a chain of plausible steps for how diverse mechanisms, despite some structural similarities, achieved their high levels of functional accuracy.1. Laura Trinkle-Mulcahy and Angus I. Lamond, “Toward a High-Resolution View of Nuclear Dynamics,” Science, 30 November 2007: Vol. 318. no. 5855, pp. 1402-1407, DOI: 10.1126/science.1142033.2. Laura J. Terry, Eric B. Shows, Susan R. Wente, “Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport,” Science, 30 November 2007: Vol. 318. no. 5855, pp. 1412-1416, DOI: 10.1126/science.1142204.3. Colin L. Stewart, Kyle J. Roux, Brian Burke, “Blurring the Boundary: The Nuclear Envelope Extends Its Reach,” Science, 30 November 2007: Vol. 318. no. 5855, pp. 1408-1412, DOI: 10.1126/science.1142034.4. Tom O. Rapoport, “Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes,” Nature 450, 663-669 (29 November 2007) | doi:10.1038/nature06384.5. Rama Ranganathan, “Signaling Across the Cell Membrane,” Science, 23 November 2007: Vol. 318. no. 5854, pp. 1253-1254, DOI: 10.1126/science.1151656.6. Alber et al, “The molecular architecture of the nuclear pore complex,” Nature 450, 695-701 (29 November 2007) | doi:10.1038/nature06405.The evolutionary speculations in Nature provided nothing to the real scientific work in these papers. They did not help determine the structure, function or dynamics of any of the transport mechanisms. They were mere after-the-fact pipe dreams about how Charlie might be vindicated with a hefty dose of LSD (Let’s Support Darwin). Gene duplication is pitifully incapable of explaining how functional information got into either clathrin-coated endocytosis or nuclear pore transport. A motorcycle and a diesel train have some similarities, too; they both have wheels that rotate and are powered by fuels that have some similarities (hydrocarbons). So what? You can duplicate as many motorcycles as you want, for eternity, and will never get a bullet train. Even if you allow the duplicate motorcycle unlimited free mutations, will that help? Try breaking things at random on the motorcycle and see if you make progress toward train technology. Darwinian evolution is blind, remember. It has no foresight. It is not trying to work toward traindom. Unless each mistake provides some advantage for the here and now, the only likely result is that repeated mutations will leave you stranded on the highway bumming a ride. Sorry we had to waste time on evolution. The focus of this story should be on the amazing mechanisms of the cell, and how modern science is slowly pulling back the cover on the package so we can all, with the fascination of kids at Christmas, look inside and see the words LION-EL.*(Visited 9 times, 1 visits today)FacebookTwitterPinterestSave分享0